Palladium Photocatalysis: A Strategic Approach for Visible-Light-Mediated C(sp)2 -H Arylation

Abstract

A strategic and energy-efficient protocol has been developed to forge C(sp)2–C(sp)2 bonds through C-H bond functionalization. Here, Pd-photoredox catalysis has been used under blue LEDs irradiation to generate aryl (or heteroaryl) radicals from the corresponding redox active iodoarenes and utilized it in C-H bond arylation. The key attraction lies in the wide functional group tolerance with impressive yield and the late-stage functionalization of natural products under mild reaction conditions. Operational simplicity and mechanistic evidence for photoinduced Pd-catalysis illustrate the promise of this approach as a comprehensive platform for sustainable aryl–aryl cross-coupling.