We report a robust method for C7-sulfonamide installation on 7-deazaadenosines, enabled by an unprecedentedly stable sulfonyl chloride. This general transformation introduces a new functionalization site and expands nucleoside chemical space, offering a powerful platform for constructing tailored probes and analogues in synthetic and bioorganic chemistry.
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M. Štefek, M. Dejmek, M. Šála and R. Nencka, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D5CC06746D
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