We report a robust method for C7-sulfonamide installation on 7-deazaadenosines, enabled by an unprecedentedly stable sulfonyl chloride. This general transformation introduces a new functionalization site and expands nucleoside chemical space, offering a powerful platform for constructing tailored probes and analogues in synthetic and bioorganic chemistry.
To support increased transparency, we offer authors the option to publish the peer review history alongside their article.
M. Štefek, M. Dejmek, M. Šála and R. Nencka, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC06746D
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