Chemoselective synthesis of α-fluoromethyl amides via the controlled addition of LiCH2F to N-aryl and N-alkyl isocyanates

Davide Castiglione; Alberto Nardi; Margherita Miele; Laura Castoldi; Vittorio Pace

doi:10.1039/D5CC06730H

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Chemoselective synthesis of α-fluoromethyl amides via the controlled addition of LiCH₂F to N-aryl and N-alkyl isocyanates†

Davide Castiglione,

^a Alberto Nardi,

^a Margherita Miele,

^a Laura Castoldi

*^b and Vittorio Pace

*^cd

Author affiliations

* Corresponding authors

^a University of Turin – Department of Chemistry, Via Giuria 7, Turin, Italy

^b University of Milan – Department of Pharmaceutical Sciences, General and Organic Chemisty Section “A. Marchesini” – Via Venezian 21, Milan, Italy
E-mail: laura.castoldi@unimi.it

^c University of Rome “La Sapienza” – Department of Chemistry, P.le A. Moro 5, Rome, Italy
E-mail: vittorio.pace@univie.ac.at, vittorio.pace@uniroma1.it

^d University of Vienna, – Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Josef-Holaubek-Platz 2, Vienna, Austria

Abstract

α-Fluoromethyl amides were prepared through the chemoselective nucleophilic addition of fluoromethyl-lithium to isocyanates.

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Article information

DOI: https://doi.org/10.1039/D5CC06730H
Article type: Communication
Submitted: 27 Nov 2025
Accepted: 23 Jan 2026
First published: 05 Feb 2026
This article is Open Access

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Chem. Commun., 2026, Advance Article

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Chemoselective synthesis of α-fluoromethyl amides via the controlled addition of LiCH₂F to N-aryl and N-alkyl isocyanates

D. Castiglione, A. Nardi, M. Miele, L. Castoldi and V. Pace, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC06730H

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