Herein, we report a novel molecular design strategy that introduces two distinct pharmacokinetic modifiers into a single radioligand to achieve the synergistic enhancement of tumor accumulation. We newly designed a small-molecule-based radioligand, which contains both a positively charged unit and an albumin binder, and demonstrated its enhanced tumor accumulation.
T. Hasegawa, K. Nakashima, H. Watanabe and M. Ono, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC06620D
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