From the journal:

Chemical Communications

A pH-responsive iron/manganese bimetallic organic framework nanosystem for synergistic therapy of colon cancer

Siyuan Wang,a   Shichen Zhang,b   Xue Jia,a   Xinran Yan,a   Yixin Tang,a   Mujie Kan,a   Chang Liu*c  and  Caina Xu ORCID logo *a  

* Corresponding authors

a College of Basic Medical Sciences, the Medical Basic Research Innovation Centre of Airway Disease in North China, Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China
E-mail: xucaina@jlu.edu.cn

b Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Jilin University, Changchun, China

c Department of Neurology and Neuroscience Centre, First Hospital of Jilin University, Changchun, China
E-mail: drliuchang@jlu.edu.cn

Abstract

A system loaded with MTO and encapsulated in SA achieved efficient drug delivery and tumor- microenvironment-triggered release. This release of MTO further exerted its chemotherapeutic effects and, in conjunction with ferroptosis, induced immunogenic cell death.

Graphical abstract: A pH-responsive iron/manganese bimetallic organic framework nanosystem for synergistic therapy of colon cancer

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Article information

DOI
https://doi.org/10.1039/D5CC06597F
Article type
Communication
Submitted
20 Nov 2025
Accepted
05 Jan 2026
First published
09 Jan 2026
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2026, Advance Article

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A pH-responsive iron/manganese bimetallic organic framework nanosystem for synergistic therapy of colon cancer

S. Wang, S. Zhang, X. Jia, X. Yan, Y. Tang, M. Kan, C. Liu and C. Xu, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC06597F

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