From the journal:

Chemical Communications

A pH-responsive iron/manganese bimetallic organic frameworks nanosystem for synergistic therapy of colon cancer

Siyuan Wang,   Shichen Zhang,   Xue Jia,   Xinran Yan,   Yixin Tang,   Mujie Kan,   Chang Liu  and  Caina Xu  

Abstract

The system, loaded with mitoxantrone (MTO) and encapsulated in sodium alginate (SA), achieved efficient drug delivery and tumor microenvironment-triggered release This release of MTO further exerted its chemotherapeutic effects and, in conjunction with ferroptosis, induced immunogenic cell death. This study provided a promising multifunctional nanoplatform for synergistic therapies of colon cancer.

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Article information

DOI
https://doi.org/10.1039/D5CC06597F
Article type
Communication
Submitted
20 Nov 2025
Accepted
05 Jan 2026
First published
09 Jan 2026
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2026, Accepted Manuscript

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A pH-responsive iron/manganese bimetallic organic frameworks nanosystem for synergistic therapy of colon cancer

S. Wang, S. Zhang, X. Jia, X. Yan, Y. Tang, M. Kan, C. Liu and C. Xu, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D5CC06597F

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