Construction of oxindole spiro medium-sized S-heterocycles via ring expansion [2,3]-sigmatropic rearrangement

Abstract

The significance of medium-sized rings is demonstrated by their being key structural cores in diverse bioactive molecules. Herein, we describe an efficient strategy for synthesizing oxindole-annulated medium-sized S-heterocycles via ring expansion [2,3]-sigmatropic rearrangement. This strategy features high substrate tolerance and yield, offering a versatile approach to such intricate skeletons.