Chemoselective nickel-catalyzed difluoromethylation of aryl halides with (SIPr)AgCF2H as transmetalation reagent

Abstract

A user-friendly method for the difluoromethylation of aryl iodides under nickel catalysis has been developed, employing readily accessible, light- and temperature-insensitive (SIPr)AgCF₂H as CF₂H source. A variety of electronically diverse arenes was smoothly transformed and the reaction displayed excellent levels of chemoselectivity, tolerating inter alia synthetically valuable triflates.