Self-Assembled Chromopeptide Nanostructures for Photothermal Therapy of Tumors

Abstract

Drawing inspiration from the elegant molecular machinery and unique light-handling functions of natural chromoproteins, this review focuses on the rational design of self-assembling chromopeptide as a versatile platform to address the enduring challenges of photothermal therapy (PTT) for tumors. These programmable constructs, which integrate photosensitive motifs with self-assembling peptide sequences, enable the bottom-up fabrication of biocompatible nanomaterials with precisely tailored photothermal properties. This review systematically explores the molecular design principles and supramolecular assembly mechanisms that underpin the exceptional performance of these nanostructures.