Histidine methyltransferases (HMTs) are AdoMet-dependent enzymes that catalyse regioselective methylation of histidine residues in proteins. Here, we demonstrate that a methionine adenosyltransferase (MAT)/HMT cascade system enables the generation and utilisation of AdoMet analogues for efficient and selective histidine methylation in peptide substrates.
Z. Yu, A. Hoffmann, A. L. Irion, M. Ram, J. Drozak, A. Rentmeister and J. Mecinović, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D5CC06375B
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