We have developed surface treatment techniques utilising radiofrequency current cold argon plasmas (RF-CAP) for non-enzymatic digestion of macromolecules, exemplified here with peptides and proteins of varying sizes. These plasmas are able to rapidly digest condensed-phase macromolecules with minimal sample preparation, producing predictable fragments visible by LC-MS analysis.
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D. McGill, D. Simon, S. Ramadurai, F. Green and Z. Takats, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC06333G
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