From the journal:

Chemical Communications

Ruthenium or Osmium? On the Role of the Metal in Carbonylchlorido Complexes for Photodynamic Therapy

Gina Elena Giacomazzo,   Fortuna Ponte,   Valentina Ceccherini,   Lorenzo Gianassi,   Gloria Mulas,   Emilia Sicilia,   Francesca Cencetti,   Barbara Valtancoli,   Luca Conti  and  Claudia Giorgi  

Abstract

Two novel carbonylchlorido complexes for photodynamic therapy (PDT), RuCOCl and OsCOCl, were synthesized via a unified synthetic strategy. Comparative photophysical, computational and preliminary biological studies reveal the crucial influence of the metal in governing their PDT performance, highlighting the potential of this largely underestimated class of complexes for PDT applications.

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Article information

DOI
https://doi.org/10.1039/D5CC06225J
Article type
Communication
Submitted
03 Nov 2025
Accepted
12 Jan 2026
First published
13 Jan 2026
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2026, Accepted Manuscript

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Ruthenium or Osmium? On the Role of the Metal in Carbonylchlorido Complexes for Photodynamic Therapy

G. E. Giacomazzo, F. Ponte, V. Ceccherini, L. Gianassi, G. Mulas, E. Sicilia, F. Cencetti, B. Valtancoli, L. Conti and C. Giorgi, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D5CC06225J

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