From the journal:

Chemical Communications

Biochar-supported Cu catalyst for low-temperature base-free oxidative N-formylation of amines with paraformaldehyde in green solvent

Haihua Yin,ab   Zhenjie Wang,ab   Hangkong Yuan*a  and  Xingchao Dai ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, No. 18, Tianshui Middle Road, Lanzhou, China
E-mail: yuanhk@licp.cas.cn, daixingchao@licp.cas.cn

b University of Chinese Academy of Sciences, No. 19 A, Yuquanlu, Beijing, China

Abstract

A novel cellulose-biochar-supported copper catalyst enables base-free oxidative N-formylation of amines with paraformaldehyde in green H2O solvent at 50 °C. This green protocol efficiently converts diverse amines into formamides, including pharmaceutical intermediates, via a radical mechanism co-mediated by ˙OH and ˙OOH species.

Graphical abstract: Biochar-supported Cu catalyst for low-temperature base-free oxidative N-formylation of amines with paraformaldehyde in green solvent

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Article information

DOI
https://doi.org/10.1039/D5CC06007A
Article type
Communication
Submitted
22 Oct 2025
Accepted
20 Nov 2025
First published
20 Nov 2025

Chem. Commun., 2026, Advance Article

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Biochar-supported Cu catalyst for low-temperature base-free oxidative N-formylation of amines with paraformaldehyde in green solvent

H. Yin, Z. Wang, H. Yuan and X. Dai, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC06007A

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