PhI(OCOCF 3 ) 2 -Mediated Metal-Free 2,3-Difunctionalization of Indoles: Direct Access to Carbochalcogenated Scaffolds

Abstract

We want to report a metal-free approach for the oxidative difunctionalization of indole moieties using a hypervalent iodine reagent. This protocol facilitates a metal-free, environmentally friendly, and efficient oxidative C(sp2)−H coupling reaction that utilises indole, naphthoquinones, and diphenyl dichalcogenides. The method is being outlined so that it should run under mild conditions to enable the formation of C(sp2)−C and C(sp2)−S/Se bonds with good yields and a wide range of relevant substrates. Additionally, our approach offers a valuable pathway for the modification of drug molecules, which further enhances its utility in organic synthesis.