Ru-catalyzed C–H annulation: accessing quinazolinone–BCP hybrids from stable precursors

Abstract

A ruthenium-catalyzed C–H annulation of benzimidates with bench-stable BCP–dioxazolone reagents enables efficient synthesis of quinazolinone–BCP hybrids. The reaction features broad substrate scope, mild conditions, and scalability. This strategy provides a versatile platform for late-stage functionalization and structural diversification of drug-like molecules bearing bicyclo[1.1.1]pentane frameworks.