Atom-Efficient Iron-Catalyzed Cascade Synthesis of Pyrroles from Nitroarenes under Low-Pressure Conditions

Abstract

Conventional pyrrole syntheses typically rely on multistep procedures or pre-functionalized substrates. Here, we report a onepot Paal-Knorr cascade reaction that directly converts nitroarenes to pyrroles. Utilizing low-pressure hydrogenation in the presence of an iron catalyst, this approach enhances atom economy and sustainability, offering an efficient and environmentally benign alternative to traditional methods.