From the journal:

Chemical Communications

Polyethyleneimine-functionalized MXene as stable two-dimensional platforms for gene delivery systems

Farhan Hadi,†a   Seoyeon Park,†b   Tae-il Kim*bc  and  Jae-Min Oh ORCID logo *a  

* Corresponding authors

a Department of Energy & Materials Engineering, Dongguk University, Seoul, Republic of Korea
E-mail: jaemin.oh@dongguk.edu

b Department of Agriculture, Forestry and Bioresources, College of Agriculture and Life Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea
E-mail: seal1004@snu.ac.kr

c Research Institute of Agriculture and Life Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea

Abstract

This study examined the influence of polyethyleneimine (PEI) molecular weight on the chemical bonding, colloidal behavior, pDNA loading, cytotoxicity, and cellular uptake of PEI–MXene hybrids. The hybrids showed reduced cytotoxicity compared with PEI, highlighting their potential as safe pDNA delivery systems.

Graphical abstract: Polyethyleneimine-functionalized MXene as stable two-dimensional platforms for gene delivery systems

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Article information

DOI
https://doi.org/10.1039/D5CC05910K
Article type
Communication
Submitted
17 Oct 2025
Accepted
03 Apr 2026
First published
16 Apr 2026

Chem. Commun., 2026, Advance Article

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Polyethyleneimine-functionalized MXene as stable two-dimensional platforms for gene delivery systems

F. Hadi, S. Park, T. Kim and J. Oh, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC05910K

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