From the journal:

Chemical Communications

A multiple signal-amplified electrochemiluminescence biosensor for ultrasensitive detection of bladder cancer-associated circRNA in urine

Jingjing Zhang,a   Xiaoman Ju,a   Ziqiang Wang,a   Lin Hao*bc  and  Jie Chao ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Flexible Electronics (LoFE), Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, School of Chemistry and Life Sciences, Nanjing University of Posts and Telecommunications, Nanjing 210023, China
E-mail: iamjchao@njupt.edu.cn

b Department of Urology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China
E-mail: 760020230028@xzhmu.edu.cn

c Kuitun Hospital of Ili Kazakh Autonomous Prefecture, Kuitun 833200, PR China

Abstract

An ultrasensitive electrochemiluminescence (ECL) biosensor was constructed for circular RNA detection by integrating an Fe-based metal–organic framework functionalized with gold nanoparticles (Fe-MOF@AuNPs) with rolling circle amplification (RCA) and cyclic amplification. The platform demonstrated excellent performance in urine samples, highlighting its potential for non-invasive early clinical diagnostics and biomedical research.

Graphical abstract: A multiple signal-amplified electrochemiluminescence biosensor for ultrasensitive detection of bladder cancer-associated circRNA in urine

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Article information

DOI
https://doi.org/10.1039/D5CC05842B
Article type
Communication
Submitted
14 Oct 2025
Accepted
25 Nov 2025
First published
02 Dec 2025

Chem. Commun., 2026, Advance Article

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A multiple signal-amplified electrochemiluminescence biosensor for ultrasensitive detection of bladder cancer-associated circRNA in urine

J. Zhang, X. Ju, Z. Wang, L. Hao and J. Chao, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC05842B

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