Electroreduction cross-coupling of thiosulfonates with (hetero)aryl boronic acids to access thioethers

Abstract

Herein, we present a robust electrochemically driven, 1-iodonaphthalene-enabled cross-coupling of thiosulfonates with arylboronic acids for the synthesis of thioether molecules. This reaction is characterized by exceptional selectivity, gentle reaction conditions, a broad substrate scope, and significant functional group tolerance that extends to late-stage modifications of biologically relevant molecules.