Cu-catalyzed selective coupling of alkynes with danB–Bpai

Abstract

A novel diboronic reagent, danB–Bpai, has been designed, and the copper-catalyzed selective transformation reaction between alkynes and this reagent has been investigated. By regulating ligands and additives, the chemoselective reaction of danB–Bpai can be achieved. The reaction exhibits excellent functional group compatibility, and synthetic experiments have confirmed that its products can serve as important synthetic precursors for a series of compounds with complex structures. Additionally, this study further examined the influence of the aromatic ring attached to the alkyne on reaction kinetics and explored the source of protons in the reaction.