From the journal:

Chemical Communications

ROS-accelerated quinone formation from gossypol in a dendritic AIE polymer enables synergistic type I photodynamic therapy and chemotherapy

Wenyan Gong,†ac   Jiaxin Cheng,†a   Dong Liu,b   Xin Hu,b   Jianwen Tian,a   Meiying Liu,*ab   Shaorong Huang,*c   Xiaoyong Zhang ORCID logo *a  and  Yen Weid  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, P. R. China
E-mail: lmy5305@iccas.ac.cn, zhangxiaoyong@ncu.edu.cn

b Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China

c Institute of Geriatrics, Jiangxi Provincial People's Hospital &, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, People's Republic of China
E-mail: huangshaorong@ncmc.edu.cn

d Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing, P. R. China

Abstract

A hyperbranched polymer photosensitizer, TPAGH, was synthesized for gossypol delivery, yielding TPAGH-GS with pH-responsive release and enhanced phototherapy via quinone-mediated Michael addition.

Graphical abstract: ROS-accelerated quinone formation from gossypol in a dendritic AIE polymer enables synergistic type I photodynamic therapy and chemotherapy

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Article information

DOI
https://doi.org/10.1039/D5CC05263G
Article type
Communication
Submitted
12 Sep 2025
Accepted
20 Mar 2026
First published
08 Apr 2026

Chem. Commun., 2026, Advance Article

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ROS-accelerated quinone formation from gossypol in a dendritic AIE polymer enables synergistic type I photodynamic therapy and chemotherapy

W. Gong, J. Cheng, D. Liu, X. Hu, J. Tian, M. Liu, S. Huang, X. Zhang and Y. Wei, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC05263G

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