From the journal:

Chemical Communications

An AI-engineered peptidyl fluorescence probe for GRP78: advancing renal cell carcinoma diagnosis

Lei Zhang,a   Kunyang An,b   Zhe Yang,b   Mei Yang,c   Hong Guo,a   Yinzhao Jia,a   Keyin Liu, ORCID logo *d   Xuezhi Liang*a  and  Caoyang Hu*a  

* Corresponding authors

a Department of Urology, First Hospital of Shanxi Medical University, Taiyuan 030000, China
E-mail: eryaoer2003@126.com

b First Clinical Medical College of Shanxi Medical University, Taiyuan 030000, China

c Department of Neurology, Shanxi Hospital of Integrated Traditional Chinese and Western Medicine, Taiyuan 030000, China

d State Key Laboratory of Green Papermaking and Resource Recycling, Qilu University of Technology, Jinan 250353, PR China

Abstract

By the integration of AI and molecular engineering, we developed an activatable peptidyl fluorescent probe targeting GRP78 with high sensitivity and specificity. The probe enabled high-contrast imaging of renal cell carcinoma in patient-derived tissue samples. AI-driven molecular engineering provides a scalable platform for developing precision diagnostics.

Graphical abstract: An AI-engineered peptidyl fluorescence probe for GRP78: advancing renal cell carcinoma diagnosis

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Article information

DOI
https://doi.org/10.1039/D5CC05238F
Article type
Communication
Submitted
11 Sep 2025
Accepted
30 Nov 2025
First published
08 Dec 2025

Chem. Commun., 2026, Advance Article

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An AI-engineered peptidyl fluorescence probe for GRP78: advancing renal cell carcinoma diagnosis

L. Zhang, K. An, Z. Yang, M. Yang, H. Guo, Y. Jia, K. Liu, X. Liang and C. Hu, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC05238F

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