The inertness of copper(II) complexes can be critical for applications such as 64Cu positron emission tomography (PET). Sequence analysis of the simple peptidic amino terminal Cu(II)- and Ni(II)-binding (ATCUN) motif showed a significant improvement by introducing a tryptophan at position 4, and a stronger influence of position 2 over 1.
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R. Djemili, E. Naudin, A. Wang, A. Ouadi, P. Gonzalez, L. Raibaut, P. Faller and V. Lebrun, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC05119C
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