Photocatalytic Oxidative Cyclopropanation of Aza-1,6-enynes: Construction of 3-Aza-bicyclo [3.1.0] hexane Derivatives

Abstract

An operationally simple, metal-free, photocatalytic approach for the synthesis of 3-aza-bicyclo[3.1.0]hexane from aza-1,6-eynes has been developed. The developed method allows the synthesis of highly decorated aza-bicyclo[3.1.0]hexane under mild reaction conditions with excellent functional group tolerance and a broad substrate scope. The control experiments well support the proposed radical pathway for the reaction. The reaction's advantageous features are operational simplicity, atom economy, metal-free free and broad substrate scope.