Helical peptides are primarily stabilized by intramolecular hydrogen bonds. Particular conformational arrangements, capping motifs, help precisely terminate helices by compensating for disruption of helical H-bonding patterns. This contribution explores if: (i) N- and C- caps are essentially the same; and, (ii) how differences impact their thermodynamic helix stabilities and folding kinetics.
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T. Mi, L. Mattes, T. Pewklang, K. Hauser and K. Burgess, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D5CC04856G
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