From the journal:

Chemical Communications

Hydroxylated iodinated boron clusters: a tunable platform for enhanced membrane transport and biocompatibility

Satoshi Yamamoto,†a   Rikuto Nakajima,†a   Yuya Hirai, ORCID logo †b   Yumiko K. Kawamura,c   Yoshimasa Makita, ORCID logo d   Taro Kitazawa,*c   Mutsumi Kimura ORCID logo *a  and  Yu Kitazawa ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Materials, Faculty of Textile Science and Technology, Shinshu University, Ueda 386-8567, Japan
E-mail: yu_kitazawa0311@shinshu-u.ac.jp, mkimura@shinshu-u.ac.jp

b Department of Biology, Osaka Dental University, Hirakata, Osaka 573-1121, Japan

c Department of Molecular Biology and Genetics, Aarhus University, Universitetsbyen 81, 8000 Aarhus, Denmark
E-mail: taro.kitazawa@dandrite.au.dk

d Department of Chemistry, Osaka Dental University, Hirakata, Osaka 573-1121, Japan

Abstract

[B12I12]2− exhibits potent membrane transport yet high cytotoxicity. Stepwise hydroxylation moderates chaotropicity, balancing permeability and biocompatibility. Notably, mono-hydroxylation retains transport activity while minimizing toxicity, whereas further hydroxylation ablates permeability. This strategy advances safe, efficient boron cluster-based carriers for drug delivery and related biomedical applications.

Graphical abstract: Hydroxylated iodinated boron clusters: a tunable platform for enhanced membrane transport and biocompatibility

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Article information

DOI
https://doi.org/10.1039/D5CC04085J
Article type
Communication
Submitted
19 Jul 2025
Accepted
08 Sep 2025
First published
10 Dec 2025

Chem. Commun., 2026, Advance Article

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Hydroxylated iodinated boron clusters: a tunable platform for enhanced membrane transport and biocompatibility

S. Yamamoto, R. Nakajima, Y. Hirai, Y. K. Kawamura, Y. Makita, T. Kitazawa, M. Kimura and Y. Kitazawa, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC04085J

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