PLATFORM UPDATE:
Gramicidin S continues to inspire antibiotic designs. It exhibits a conserved two-fold (C2) symmetry postulated to underpin its biological activity. Here we probe the C3 symmetry of Gramicidin S and its impact on the folding and antibacterial properties of this antibiotic.
A. Hoose, J. Garcia-Ruiz, C. C. M. Lally, C. Dondi and M. Ryadnov, RSC Chem. Biol., 2026, Accepted Manuscript , DOI: 10.1039/D6CB00134C
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