PLATFORM UPDATE:
We report a noncanonical amino acid-containing photoconvertible fluorescent protein for selective peroxynitrite detection. Incorporation of p-borono-L-phenylalanine into circularly permuted mEos2 affords a peroxynitrite-responsive sensor that retains photoconversion capability, expanding chemical diversity in light-controllable fluorescent proteins.
G. Roman Arocho, P. Das, S. Tennakoon, J. Shaw, W. Niu and J. Guo, RSC Chem. Biol., 2026, Accepted Manuscript , DOI: 10.1039/D6CB00083E
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