Surface Modification of Intraocular Lens with Zwitterionic Poly(Carboxybetaine) for Posterior Capsular Opacification Prevention

Abstract

Posterior capsular opacification (PCO) remains the most common long-term complication after cataract surgery, primarily caused by residual lens epithelial cells (LEC) adhesion and proliferation on the intraocular lens (IOL) surface. Here, we report a zwitterionic carboxybetaine coating strategy to endow IOLs with anti-adhesive and anti-fibrotic properties without compromising optical clarity. The zwitterionic monomer carboxybetaine methacrylate (CBMA) was grafted onto IOL surface via plasma activation, forming a stable antifouling interface. The CBMA-coated surface exhibited a reduced water contact angle and a smooth, uniform morphology while preserving optical transparency. Both anti-adhesion assays and IOL implantation studies confirmed that the highly antifouling CBMA coating markedly inhibited LEC adhesion, suppressed PCO formation, and maintained excellent biocompatibility. This work establishes a surface modification approach that integrates zwitterionic chemistry with clinical biomaterials, providing a promising pathway toward next-generation IOLs with intrinsic PCO-preventive functionality.