Cyclic peptide-based shear-thinning and self-healing hydrogels as injectable nanotherapeutics

Abstract

An injectable cyclic peptide-based hydrogel (cpGel) governed by supramolecular interactions between cyclic octapeptide nanofibers and nanosilicates was developed. We demonstrated its excellent injectability, elasticity, and self-healing properties through rheological analyses. Further, we showed that cpGel is cytocompatible and that vancomycin-loaded cpGel can effectively inhibit the growth of MRSA and E. coli.