Issue 19, 2026
From the journal:

Analytical Methods

PolyA-tail-mediated assembly of a gold nanoparticle-based turn-on fluorescent aptasensor for ultrasensitive detection of perfluorooctanoic acid

Zhuo-Ying Li,ab   Li-Xia Yan,c   Xu Zhao, ORCID logo ab   Hua Lin,d   Li-Jian Chen ORCID logo *ab  and  Xiu-Ping Yan ORCID logo ab  

* Corresponding authors

a Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China

b Key Laboratory of Screening, Prevention, and Control of Food Safety Risks, State Administration for Market Regulation, Wuxi 214122, China

c Analysis and Testing Center, Jiangnan University, Wuxi 214122, China
E-mail: chenlijian123@jiangnan.edu.cn

d Food Safety Detection Key Laboratory of Sichuan Province, Chengdu 610041, China

Abstract

A turn-on fluorescent aptasensor for PFOA is developed using a polyA-tailed aptamer anchored on gold nanoparticles and a fluorescently labeled cDNA. The displacement of cDNA by PFOA restores fluorescence, enabling ultrasensitive detection with a 1.3 nmol Lāˆ’1 limit, demonstrated by satisfactory recovery in spiked fish samples.

Graphical abstract: PolyA-tail-mediated assembly of a gold nanoparticle-based turn-on fluorescent aptasensor for ultrasensitive detection of perfluorooctanoic acid

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D6AY00236F
Article type
Communication
Submitted
08 Feb 2026
Accepted
03 May 2026
First published
05 May 2026

Anal. Methods, 2026,18, 3928-3932

Permissions

Request permissions

PolyA-tail-mediated assembly of a gold nanoparticle-based turn-on fluorescent aptasensor for ultrasensitive detection of perfluorooctanoic acid

Z. Li, L. Yan, X. Zhao, H. Lin, L. Chen and X. Yan, Anal. Methods, 2026, 18, 3928 DOI: 10.1039/D6AY00236F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements