Analysis of Cholesterol Induced Mechanical Modulation of Cell Membrane by Nanopipette-Generated Fluid Flow

Abstract

Here, we report a label-free membrane oscillation strategy based on nanopipette-generated fluid flow to investigate cholesterol-induced mechanical alterations in living cell membranes. The assay relies on ionic current fluctuations to reveal the relationship between cholesterol content and membrane mechanical properties.

Supplementary files

Article information

Article type
Communication
Submitted
21 Jan 2026
Accepted
20 Apr 2026
First published
20 Apr 2026

Analyst, 2026, Accepted Manuscript

Analysis of Cholesterol Induced Mechanical Modulation of Cell Membrane by Nanopipette-Generated Fluid Flow

S. Xu, M. Zhao, X. Liu, M. Ye, B. B. Chen, D. Li, M. E. Hafez, J. Lv and R. Qian, Analyst, 2026, Accepted Manuscript , DOI: 10.1039/D6AN00067C

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