Correlative photothermal infrared nanospectroscopy (AFM-IR) and non linear optical microscopy analyses reveal that the emergence of a 1730 cm−1 IR band in collagen arises from local, thermally induced esterification. This band serves as a marker of irreversible molecular alteration, associated with structural destabilisation and chemical changes within the collagen matrix.
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J. Mathurin, G. Latour, G. Mosser, A. Dazzi, M. Schanne-Klein and A. Deniset-Besseau, Analyst, 2026, Advance Article , DOI: 10.1039/D5AN01298H
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