A direct route to ynones: Pd-catalyzed Sonogashira carbonylative coupling of ethers with alkynes via C–O cleavage
Abstract
Herein, we report a catalytic strategy that directly utilizes benzylic ethers as coupling partners through a palladium/copper co-catalyzed pathway. The reaction exhibits broad substrate scope, accommodating a wide range of functionalized benzylic alcohols and terminal alkynes, and provides direct access to valuable ynones.

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