Patient-convenient long-term alopecia treatment via PLGA microsphere-loaded candlelit microneedles

Abstract

Androgenetic alopecia (AGA) is characterized by chronic and progressive hair loss, with associated psychological factors intensifying the impact on patients. Current treatments, such as oral finasteride and topical minoxidil, have low bioavailability and numerous side effects. Dissolvable microneedles (DMNs) provide a promising alternative for drug delivery. However, the presence of hair on the scalp often hinders their insertions and adhesion. Thus, candlelit microneedles (CMNs) have been developed to improve insertion and drug delivery without the use of adhesive patches. In this study, CMNs were combined with poly lactic-co-glycolic acid (PLGA) microspheres encapsulating the NO-releasing PDE5 inhibitor TOP-M119 (M119), a potent vasodilator promoting hair growth, for sustained drug release. When delivered via the CMN, it bypasses the challenges posed by hair on the scalp. The CMN system with PLGA microspheres resulted in substantial hair growth and reduced application frequency in vivo. This indicates that it may be a more effective treatment for alopecia than conventional methods. Furthermore, the reduced application frequency may result in better patient compliance.

Graphical abstract: Patient-convenient long-term alopecia treatment via PLGA microsphere-loaded candlelit microneedles

Supplementary files

Article information

Article type
Paper
Submitted
17 Jan 2025
Accepted
10 Mar 2025
First published
13 Mar 2025
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2025, Advance Article

Patient-convenient long-term alopecia treatment via PLGA microsphere-loaded candlelit microneedles

J. Shin, S. M. Cho, Y. Kim, G. Kang, T. Braun, H. Tenor, C. Ludin, R. Naef and H. Jung, J. Mater. Chem. B, 2025, Advance Article , DOI: 10.1039/D5TB00118H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements