Issue 9, 2025

Dual-functional guanosine-based hydrogel: high-efficiency protection in radiation-induced oral mucositis

Abstract

Radiation-induced oral mucositis (RIOM) is the most common adverse effect experienced by cancer patients following radiotherapy; however, effective clinical treatments remain insufficiently recognized. In this study, a guanosine-polyvinyl alcohol (G-PVA) supramolecular hydrogel was developed using a one-pot synthesis method. The G-PVA hydrogel demonstrated remarkable wet adhesion properties measuring 74.16 kPa (±3.53 kPa), biocompatibility and shape adaptability, making it suitable for the dynamic conditions of the oral cavity. Under radiation exposure, the G-PVA hydrogel not only mitigated oxidative stress but also provided effective protection to cells against direct damage, as shown by the decrease in the number of γ-H2AX foci from 79.81% (±1.33%) to 5.70% (±0.88%) and 17.12% (±3.44%), respectively. In vivo investigations further validated that the G-PVA hydrogel significantly reduced RIOM, with a decrease in the relative ulcerative area by 52.23% in comparison to the IR group. This dual-functional supramolecular hydrogel may represent a promising new clinical strategy for the prevention of RIOM in the future.

Graphical abstract: Dual-functional guanosine-based hydrogel: high-efficiency protection in radiation-induced oral mucositis

Supplementary files

Article information

Article type
Paper
Submitted
23 Oct 2024
Accepted
17 Jan 2025
First published
03 Feb 2025

J. Mater. Chem. B, 2025,13, 3039-3048

Dual-functional guanosine-based hydrogel: high-efficiency protection in radiation-induced oral mucositis

Z. Ding, X. Hu, W. Liang, S. Zheng, X. Luo and H. Zhao, J. Mater. Chem. B, 2025, 13, 3039 DOI: 10.1039/D4TB02380C

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