Issue 28, 2025

Splay and bend deformations in cells near corners

Abstract

The study of spindle-like cells as nematic liquid crystals has led to remarkable insights in the understanding of tissue organization and morphogenesis. In the characterization of this anomalous liquid crystal material, we focus on the energetic cost of splay and bend deformations, in order to determine the elastic anisotropy of the material, i.e. the ratio of the elastic constants associated with splay and bend. We explore the behavior of monolayers of cells in proximity to corners, where cells arrange in splay or bend configuration, depending on the amplitude of the wedge angle. The angle at which splay and bend deformations are equally likely is determined by the ratio between splay and bend elastic constants. Our data suggest that for fibroblast cells the common approximation of bend and splay constants being equal is valid.

Graphical abstract: Splay and bend deformations in cells near corners

Supplementary files

Article information

Article type
Paper
Submitted
29 Jan 2025
Accepted
12 Jun 2025
First published
26 Jun 2025

Soft Matter, 2025,21, 5804-5812

Splay and bend deformations in cells near corners

A. Murali, P. Awasthi, K. Endresen, A. Goszczak and F. Serra, Soft Matter, 2025, 21, 5804 DOI: 10.1039/D5SM00093A

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