Unassisted visible-light driven NADH regeneration based on the dual photoelectrodes system

Abstract

NADH regeneration is crucial for biocatalytic processes. One promising candidate is visible-light driven NADH regeneration using water as an electron source. Herein, the visible-light driven electrochemical NADH regeneration using water as an electron source without an external bias by combination of IrOx/TaON (or RhOx/TaON) photoanode, CdS/CuInS₂ photocathode and [Cp*Rh(bpy)(H₂O)]²⁺ as a catalyst for regioselective NAD⁺ reduction is demonstrated for the first time. Furthermore, to apply this system to the production of L-lactate from pyruvate using lactate dehydrogenase was attempted.