Towards electrochemical sensing of gemcitabine release from hybrid nanoparticles in pancreatic cancer cells

Abstract

Theranostic clinical translation has been hindered by the lack of analytical tools facilitating interrogation. Here we report the detection of a chemotherapeutic agent, gemcitabine, released via heat trigger, from a hybrid iron oxide–gold theranostic nanoparticle surface in vitro in pancreatic cancer cells by electrochemiluminescence directly addressing this analytical gap.