Intermolecular photo-redox reaction between nitroarenes and phenylmethylamines under continuous photo-flow conditions

Abstract

Intermolecular photo-redox reactions can promote a wide range of chemical transformations. It is challenging to predict the photo-induced redox reaction for the intermolecular transfer of hydrogen and oxygen atoms. Herein, we have reported a strategy for transferring the intermolecular redox activity between nitroarenes and phenylmethylamines to make aromatic amines, aldehydes, and imines. The approach successfully synthesizes useful drug intermediates as well as final drug compounds, showcasing its efficiency and versatility. This protocol highlights significant practical utility in advanced organic synthesis.