The “factory in a lab”: telescoping the Matteson and Matteson–Hoppe–Aggarwal boronate chemistry under flow conditions

Abstract

The Matteson reaction and the related Matteson–Hoppe–Aggarwal variant were combined in a compartmentalized flow system and the doubly homologated resulting boronate was transformed into the corresponding alcohols after terminal oxidation. Terpenoids were included allowing the generation of new terpene alcohols in excellent yields which were evaluated for their olfactory properties.