Lendenfeldaranes W–Y, new 24-homoscalaranes from a marine sponge Lendenfeldia species

Chih-Yin Huang; Bo-Rong Peng; Yueh-Wen Liu; You-Ying Chen; Jui-Hsin Su; Chia-Ching Liaw; Jih-Jung Chen; Chung-Chih Tseng; Yu-Jen Wu; Yuan-Bin Cheng; Lun Kelvin Tsou; Mingzi M. Zhang; Zhi-Hong Wen; Li-Guo Zheng; Ping-Jyun Sung

doi:10.1039/D5RA07083J

Lendenfeldaranes W–Y, new 24-homoscalaranes from a marine sponge Lendenfeldia species

Chih-Yin Huang,^ab Bo-Rong Peng,^c Yueh-Wen Liu,^d You-Ying Chen,^e Jui-Hsin Su,

^efg Chia-Ching Liaw,

^hijkl Jih-Jung Chen,

^j Chung-Chih Tseng,^bm Yu-Jen Wu,ⁿ Yuan-Bin Cheng,^g Lun Kelvin Tsou,^o Mingzi M. Zhang,

^p Zhi-Hong Wen,^eg Li-Guo Zheng

*^eq and Ping-Jyun Sung

*^egirstu

Author affiliations

* Corresponding authors

^a Department of Orthopedics, Kaohsiung Armed Forces General Hospital, Kaohsiung 802301, Taiwan

^b Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804201, Taiwan

^c Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan

^d Department of Cosmetics and Fashion Styling, Chien Shiu University, Kaohsiung 833301, Taiwan

^e National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan
E-mail: t0919928409@gmail.com, pjsung@nmmba.gov.tw

^f Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944401, Taiwan

^g Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan

^h National Research Institute of Chinese Medicine, MOHW, Taipei 112304, Taiwan

ⁱ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807378, Taiwan

^j Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chian Tung University, Taipei 112304, Taiwan

^k Department of Biochemical Science and Technology, National Chiayi University, Chiayi University, Chiayi 600048, Taiwan

^l School of Chinese Medicine, National Yang Ming Chian Tung University, Taipei 112304, Taiwan

^m School of Dentistry, College of Oral Medicine, National Defence Medical University, Taipei 114201, Taiwan

ⁿ Yu Jun Biotechnology Co., Ltd, Donggang, Pingtung 928003, Taiwan

^o Institute of Biotechnology and Pharmaceutical Research, National Health Research Institute, Miaoli 350401, Taiwan

^p Institute of Molecular and Genomics Medicine, National Health Research Institute, Miaoli 350401, Taiwan

^q Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804201, Taiwan

^r Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404394, Taiwan

^s Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei City 242062, Taiwan

^t Department of Biochemistry and Molecular Medicine, National Dong Hwa University, Hualien 974301, Taiwan

^u School of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan

Abstract

Three new scalarane-type sesterterpenoids, lendenfeldaranes W–Y (1–3), along with a known analogue, lendenfeldarane D (4), were isolated from a marine sponge identified as Lendenfeldia species. The structures of all isolates were determined based on spectroscopic methods. Scalarane 1 exhibited significant activity in enhancing alkaline phosphatase (ALP) activity.

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Lendenfeldaranes W–Y, new 24-homoscalaranes from a marine sponge Lendenfeldia species

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