Nickel-catalyzed Chan–Lam coupling: an efficient route to N-arylated 2-aminobenzothiazoles under ambient conditions

Abstract

A nickel-catalyzed C–N coupling of 2-aminobenzothiazoles and aryl boronic acids under mild reaction conditions is disclosed. The reaction afforded N-arylated 2-aminobenzothiazoles in the presence of a Ni/4,4′-dOMebpy catalytic system under open-air conditions. The method encompasses a wide range of applicable substrates, including aryl boronic acids and 2-aminobenzothiazoles, affording the corresponding C–N coupled products in moderate to good yields in short reaction times.