Chiral binaphthol-catalyzed enantioselective conjugate addition of alkenyl trifluoroborate salts to alkenyl-substituted benzothiazoles

Abstract

The chiral binaphthol-catalyzed enantioselective conjugate addition of alkenyl trifluoroborate salts to alkenyl-substituted benzothiazoles is reported, providing the 1,4-addition products in moderate to high yields and excellent enantioselectivities (up to >99% ee). This scalable catalytic system exhibits high efficiency and broad substrate scopes. Additionally, alkenyl-substituted benzoxazole was also compatible with standard conditions.