Issue 49, 2025
From the journal:

RSC Advances

Direct vicinal halo-nitration of unsaturated compounds: an overview

Zahra Azizi,*a   Zinatossadat Hossaini,b   Soumya V. Menon,c   Shahrzad Abdolmohammadi,*d   Ruya Yilmaz Saber,e   Subhashree Ray,f   Karthikeyan Jayabalan,g   Aashna Sinhah  and  Esmail Vessally ORCID logo *ij  

* Corresponding authors

a Department of Chemistry, Ka.C., Islamic Azad University, Karaj, Iran
E-mail: zahra.azizi@kiau.ac.ir

b Department of Chemistry, QaS.C., Islamic Azad University, Qaemshahr, Iran

c Assistant Professor, Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India

d Department of Chemistry, ST.C., Islamic Azad University, Tehran, Iran
E-mail: sh.abdolmohammadi@iau.ac.ir

e Medical Device Technology Engineering, Al-Turath University, Al Mansour, Baghdad 10013, Iraq

f Department of Biochemistry, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha-751003, India

g Department of Chemistry, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India

h School of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal University Dehradun, Uttarakhand, India

i Department of Chemistry, Payame Noor University, Tehran, Iran
E-mail: vessally@yahoo.com

j Composite Materials Scientific Research Center of Azerbaijan State University of Economics (UNEC), 194 M.Mukhtarov Str., Baku, Azerbaijan

Abstract

In this review, we spotlight the methodologies for the direct synthesis of β-halo nitroalkanes and nitroalkenes from the corresponding unsaturated hydrocarbons through vicinal halo-nitration strategies. The review is organized into two main sections: halo-nitration of alkenes and halo-nitration of alkynes. Both seminal works and recent advancements are discussed, with a particular emphasis on the mechanistic aspects of the reactions.

Graphical abstract: Direct vicinal halo-nitration of unsaturated compounds: an overview

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Article information

DOI
https://doi.org/10.1039/D5RA05815E
Article type
Review Article
Submitted
08 Aug 2025
Accepted
01 Oct 2025
First published
03 Nov 2025
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2025,15, 42087-42098

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Direct vicinal halo-nitration of unsaturated compounds: an overview

Z. Azizi, Z. Hossaini, S. V. Menon, S. Abdolmohammadi, R. Yilmaz Saber, S. Ray, K. Jayabalan, A. Sinha and E. Vessally, RSC Adv., 2025, 15, 42087 DOI: 10.1039/D5RA05815E

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