Issue 44, 2025, Issue in Progress
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RSC Advances

A review on the sulfur ylide-mediated Corey–Chaykovsky reaction: a powerful approach to natural product synthesis

Ammara,a   Asim Mansha,a   Samreen Gul Khan,a   Ameer Fawad Zahoor, ORCID logo *a   Muhammad Jawwad Saif, ORCID logo b   Bushra Parveen,a   Muhammad Athar Saeed, ORCID logo c   Aijaz Rasool Chaudhry,d   Ahmad Irfane  and  Muhammad Abbas ORCID logo *f  

* Corresponding authors

a Department of Chemistry, Government College University Faisalabad, 38000-Faisalabad, Pakistan
E-mail: fawad.zahoor@gcuf.edu.pk

b Department of Applied Chemistry, Government College University Faisalabad, 38000-Faisalabad, Pakistan

c Department of Chemistry and Biochemistry, Auburn University, 36849 Alabama, USA

d Department of Physics, College of Science, University of Bisha, P. O. Box 551, Bisha 61922, Saudi Arabia

e Department of Chemistry, College of Science, King Khalid University, P. O. Box 9004, Abha 61413, Saudi Arabia

f Department of Chemistry, Forman Christian College University, Lahore, Pakistan
E-mail: muhammadabbas@fccollege.edu.pk

Abstract

The Corey–Chaykovsky reaction is an efficient transformation in organic syntheses, which enables the construction of 3-membered cores via a sulfur ylide-mediated process. The reaction enables a simple yet versatile strategy to access cyclopropanes, epoxides and aziridines. The resulting cyclic frameworks are significantly valuable for the synthesis of several structurally complex compounds, including numerous natural products and their analogues. This review underscores the importance and utility of the Corey–Chaykovsky reaction towards the total synthesis of several classes of natural products reported since 2020.

Graphical abstract: A review on the sulfur ylide-mediated Corey–Chaykovsky reaction: a powerful approach to natural product synthesis

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Article information

DOI
https://doi.org/10.1039/D5RA04921K
Article type
Review Article
Submitted
10 Jul 2025
Accepted
04 Sep 2025
First published
06 Oct 2025
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2025,15, 37125-37151

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A review on the sulfur ylide-mediated Corey–Chaykovsky reaction: a powerful approach to natural product synthesis

Ammara, A. Mansha, S. G. Khan, A. F. Zahoor, M. J. Saif, B. Parveen, M. A. Saeed, A. R. Chaudhry, A. Irfan and M. Abbas, RSC Adv., 2025, 15, 37125 DOI: 10.1039/D5RA04921K

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