Issue 31, 2025

Muhenrins A–C, pimarane-type diterpenoids from Munronia henryi

Abstract

Three undescribed pimarane-type diterpenoids, muhenrins A–C (1–3), along with a known analogue were isolated from the petroleum ether extract of Munronia henryi (Meliaceae). Their structures, including absolute configurations, were elucidated by means of various spectroscopic methods (IR, UV, HR-ESI-MS, NMR), single-crystal X-ray diffraction, ECD and NMR calculations. Muhenrin A (1) features a unique 6,7-seco pimarane skeleton, and its putative biosynthetic pathways have been proposed. Compounds 1–4 showed weak inhibitory activity against NO production in LPS-induced RAW 264.7 cells, with inhibition rates ranging from 13.73 – 32.35% at 50 μM concentrations.

Graphical abstract: Muhenrins A–C, pimarane-type diterpenoids from Munronia henryi

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Article information

Article type
Paper
Submitted
25 Jun 2025
Accepted
08 Jul 2025
First published
18 Jul 2025
This article is Open Access
Creative Commons BY license

RSC Adv., 2025,15, 25542-25547

Muhenrins A–C, pimarane-type diterpenoids from Munronia henryi

W. Su, X. Hou, L. Zhang, L. Yan, Z. Tang, Y. Yu, J. Liu, Y. Sun and G. Wang, RSC Adv., 2025, 15, 25542 DOI: 10.1039/D5RA04525H

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