A two-decade overview of oxadiazole derivatives as promising anticancer agents

Abstract

One of the most difficult illnesses that people today must deal with is cancer. It is distinguished by aberrant cell division and growth, which results in the development of tumors and lumps. The heterocyclic nucleus has drawn a lot of interest in the field of chemotherapeutics; moreover, it is essential in medicinal chemistry. Oxadiazole is a nitrogen–oxygen heterocyclic core with five members that exhibits remarkable anticancer properties. Inhibiting different enzymes and growth factors is the mechanism linked to tumor defeat. This review has covered research conducted over the past 20 years as well as their potential applications in drug development as antineoplastic agents, given the significance of oxadiazole and its derivatives in this global panic problem. This review aims to highlight the anticancer properties of 1,3,4-oxadiazole and its derivatives, 1,2,4-oxadiazole.