Frontiers in bond construction: innovative approaches to C–C and carbon–heteroatom (C–S, C–N, C–O, C–Se, C–P) transformations-a review

Abstract

This comprehensive review explores the cutting-edge innovations driving modern bond construction, with a specific focus on C–C and carbon-heteroatom (C–S, C–N, C–O, C–Se, C–P) transformations. It critically examines how groundbreaking catalytic strategies including transition-metal catalysis, solid-face, photolytic protocols, and organocatalytic systems are revolutionizing synthetic methodologies by enabling unprecedented levels of selectivity, functional group tolerance, and operational simplicity under mild reaction conditions. The review dissects of these transformations, highlighting how advanced reaction protocol has paved the way for the rational design of next-generation catalytic methodology that overcomes classical synthetic limitations. Emphasis is placed on sustainable and environmentally benign approaches that integrate with green chemistry principles, thus broadening the applicability of these methods in the synthesis of complex molecules for pharmaceuticals, materials science, and other interdisciplinary applications. Future perspectives, challenges, and emerging trends are also discussed, offering valuable insights into the ongoing evolution of bond construction strategies and setting the stage for continued innovation in organic synthesis.