Design and catalytic application of Zr based metal–organic framework with pillared layer mixed ligands for the synthesis of pyrazolo[3,4-b]pyridine derivatives via a cooperative vinylogous anomeric-based oxidation

Abstract

The post-synthesis of metal–organic frameworks (MOFs) plays a valuable role in enhancing their properties and functionalities. Herein a pillared layer mixed ligand metal–organic framework, derived (DMOFs) from 2-aminoterephthalic acid (BDC-NH₂) as an O-donor and 1,4-diazabicyclo[2.2.2]octane (DABCO) as a N-donor linker based on Zr as a metal, which is functionalized with Cu(OAc)₂ as a high-efficiency heterogonous catalyst for the synthesis of pyrazolo[3,4-b]pyridine derivatives. This presented work emphasizes the importance of the designability of an MOF and its multiple applications in organic chemistry, especially the synthesis of biologically active candidate compounds while considering the green chemistry principles.