Beckmann rearrangement of ketoximes for accessing amides and lactams promoted by a perimidine-2-thione supported Hg(ii) complex: a mechanistic perception

Abstract

In this study, we present a new distorted tetrahedral mononuclear mercury(II) complex mediated by a 1-isopropyl-1H-perimidine-2(3H)-thione ligand, with a molecular formula C₂₈H₂₈Cl₂HgN₄S₂. Several characterization techniques, such as single-crystal X-ray diffraction, NMR, and FT-IR, were employed to analyze the complex. The synthesized complex acted as a metallic Lewis acid catalyst for the conversion of a wide array of ketoximes into amides and lactams, resulting in an expansion of the Beckmann rearrangement. Different types of substrates were successfully converted into corresponding amides under mild reaction conditions.